Contrave vs. Orlistat
Contrave and Orlistat differ in mechanisms and outcomes. Contrave combines naltrexone and bupropion to influence appetite and reward pathways for chronic weight management, achieving moderate weight loss. Orlistat, a lipase inhibitor, blocks fat absorption, delivering modest weight loss without appetite suppression. Contrave’s side effects include mood changes and insomnia, while Orlistat is associated with gastrointestinal issues like oily stools. Contrave costs $300/month, significantly more than Orlistat’s $100/month. Neither drug currently faces shortages.
Bupropion enhances dopamine and norepinephrine activity, reducing appetite and cravings; Naltrexone modulates the brain’s reward system, reducing cravings and emotional eating behaviors by blocking opioid receptors.
Common Side Effects
Nausea, constipation, headache, dizziness, dry mouth, and insomnia.
Serious Potential Side Effects
Increased blood pressure, seizures (rare), suicidal thoughts, and liver damage.
Blocks the breakdown and absorption of dietary fat in the intestines. Unabsorbed fat is excreted in the stool, reducing calorie intake and promoting weight loss.
Common Side Effects
Oily or fatty stools, frequent bowel movements, flatulence with discharge, and abdominal discomfort.
Serious Potential Side Effects
Rare liver damage and malabsorption of fat-soluble vitamins (A, D, E, K), kidney problems, and severe allergic reactions